Endothelial-mesenchymal transition in atherosclerotic lesion calcification
نویسندگان
چکیده
منابع مشابه
Endothelial-Mesenchymal Transition in Vascular Calcification of Ins2Akita/+ Mice
Endothelial-mesenchymal transition (EndMT) drives endothelium to contribute to normal development and disease processes. Here, we report that EndMTs occur in the diabetic endothelium of Ins2Akita/wt mouse, and show that induction of sex determining region Y-box 2 (Sox2) is a mediator of excess BMP signaling that results in activation of EndMTs and increased vascular calcification. We also find ...
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RATIONALE Endothelial cells have the ability to undergo endothelial-mesenchymal transitions (EndMTs), by which they acquire a mesenchymal phenotype and stem cell-like characteristics. We previously found that EndMTs occurred in the endothelium deficient in matrix γ-carboxyglutamic acid protein enabling endothelial cells to contribute cells to vascular calcification. However, the mechanism respo...
متن کاملCorrigendum: Endothelial to mesenchymal transition is common in atherosclerotic lesions and is associated with plaque instability
Endothelial to mesenchymal transition (EndMT) plays a major role during development, and also contributes to several adult cardiovascular diseases. Importantly, mesenchymal cells including fibroblasts are prominent in atherosclerosis, with key functions including regulation of: inflammation, matrix and collagen production, and plaque structural integrity. However, little is known about the orig...
متن کاملEndothelial to mesenchymal transition is common in atherosclerotic lesions and is associated with plaque instability
FACS histo confirmed model (no tamoxifen WT and t CD45 (AP events de 0.09 ± 0.0 versus en entary Fig. 1. ogram of per d that >50% o ot presented n‐induced end tamoxifen‐ind PC conjugated etected in the 05 % (n = 4), d.SclCreER T ;R. Specificity o ripheral leuko of all periphe). (b) Repres d.SclCreER T ;R duced, HFD‐f d) and Yfp (d e FITC channe which did n R26RstopYfp;A of endothelia ocytes fro...
متن کاملEndothelial-to-mesenchymal transition in pulmonary hypertension.
BACKGROUND The vascular remodeling responsible for pulmonary arterial hypertension (PAH) involves predominantly the accumulation of α-smooth muscle actin-expressing mesenchymal-like cells in obstructive pulmonary vascular lesions. Endothelial-to-mesenchymal transition (EndoMT) may be a source of those α-smooth muscle actin-expressing cells. METHODS AND RESULTS In situ evidence of EndoMT in hu...
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ژورنال
عنوان ژورنال: Atherosclerosis
سال: 2016
ISSN: 0021-9150
DOI: 10.1016/j.atherosclerosis.2016.08.046